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Authors
Affiliations
1 Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 461-463
Abstract
Two simple, accurate, precise, methods were developed for the estimation of Abacavir sulfate and Lamivudine in Tablet dosage form. Both the drugs are used against the HIV infection as reverse transcriptase inhibitors. Method A is Simultaneous equation method, wavelength selected for Quantitation are 284.0 nm and 270.0 nm for Abacavir sulfate (ABAC) and Lamivudine (LAM) respectively which are the λmax of both the drugs. Method B is Q-Analysis method, wavelength selected were 284.0 nm (λmax of ABAC) and 265.0 nm (Isobestic point) for the analysis. In both the methods linearity for detector response was observed in the concentration range of 5-30 mcg/ml for ABAC and LAM respectively. The proposed methods were successfully applied for the simultaneous determination of both the drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
Keywords
Abacavir Sulfate, Lamivudine, Simultaneous Equation Method and Q-Analysis Method.
